Jun-tao Guo, Ph.D.

Jun-tao Guo is an assistant professor in the Department of Bioinformatics and Genomics, College of Computing and Informatics, University of North Carolina at Charlotte. Before joining UNC Charlotte in August 2007, he was an assistant research scientist in the Department of Biochemistry and Molecular Biology and an associate member of the Institute of Bioinformatics at the University of Georgia. He received his Ph.D. degree in Molecular and Cellular Biochemistry and a Master's degree in Computer Science from the University of Kentucky in 2001 and 2002 respectively. He started his bioinformatics career at Oak Ridge National Laboratory (ORNL) as a postdoctoral research associate. His research interests are in the broad area of structural bioinformatics. Specifically, he is interested in proteins structure prediction, protein-DNA interactions and their applications in deciphering biological regulatory networks through an integrated methodology of computational prediction and wet-lab experiment. He is also interested in the evolution of regulatory pathways.

Research Areas:

Protein-DNA interactions

Alternative splicing

Evolution of biological pathways

Protein structure prediction

Recent Publications:

• Liu, Z.* Guo, J-T.* Li, T. Xu, Y. "Structure-based recognition of binding sites of transcription factors using an efficient protein-DNA docking approach", Proteins: Structure, Function, and Bioinformatics, 72(4), 1114-1124, 2008. *equal contribution
• Ellrott, K. Guo, J-T. Olman, V. Xu, Y. "Improving the performance of protein threading using Insertion/Deletion Frequency Arrays" Journal of Bioinformatics and Computational Biology (By invitation), 6(3):585-602, 2008
• Guo, J-T. Xu, Y. "Toward Modeling of Amyloid Fibril Structures" Frontiers in Bioscience, 13:4039-4050, 2008
• Guo, J-T. Ellrott, K. Xu, Y. "A historical perspective of template-based protein structure prediction", Methods Mol Biol., 413:3-42, 2008
• Guo, J-T. Jaromczyk, JW. Xu, Y. "Analysis of Chameleon Sequences and Their Implications in Biological Processes", Proteins: Structure, Function, and Bioinformatics, 67(3):548-58, 2007
• Guo,J-T. Hall, C. Xu, Y. and Wetzel, R. "Modeling Protein Aggregate Assembly and Structure", Computational Methods for Protein Structure Prediction and Modeling, 279-317, 2006
• Guo, J-T. and Xu, Y. "Computational approaches to amyloid beta fibril core structures", Methods in Enzymology, 412:300-314, 2006.
• Guo, J-T. Ellrott, K. Chung, WJ. Xu, D. Passovets, S. Xu, Y. "PROSPECT-PSPP: An Automatic Computational Pipeline for Protein Structure Prediction", Nucleic Acids Res., 2004, 32:W522-5.
• Guo, J-T. Wetzel, R. Xu, Y. "Molecular Modeling of the Core of Abeta Amyloid Fibrils", Proteins: Structure, Function, and Bioinformatics, 57(2):357-364, 2004.
• Guo, J-T. Xu, D. Kim, D. Xu, Y. "Improving the Performance of DomainParser for Structural Domain Partition Using Neural Network". Nucleic Acids Res. 31(3), 944-952, 2003.
• Guo, J-T. Yu, J. Grass, D. de beer, F.C. Kindy, M.S. "Inflammation Dependent Cerebral Deposition of Serum Amyloid A Protein in a Mouse Model of Amyloidosis". J. Neurosci. 2002, July 15, 22(14) 5900-5909